Main Outcomes and Measures The prespecified main outcomes were OS, PFS, and TRM. All statistics were pooled by applying a random-effects model. The study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses ( PRISMA) reporting guideline.ĭata Extraction and Synthesis Data on study design, individual characteristics, and outcomes were extracted. Thirty trials were included in the meta-analysis. Study Selection After duplicate and irrelevant publications were discarded, 329 were ineligible according to the inclusion (clinical trials or retrospective studies with >10 samples) and exclusion criteria (articles without overall survival, progression-free survival, and transplantation-related mortality ). Objective To compare the effectiveness and safety of allogeneic HSCT vs autologous HSCT in patients with R/R-PTCL.ĭata Sources A systematic search of the PubMed, Embase, the Cochrane Central Register of Controlled Trials, Wanfang, and China National Knowledge Infrastructure databases with the search items refractory or relapsed peripheral T-cell lymphoma, ASCT/autologous stem-cell transplantation, allo-HSCT/allogeneic stem-cell transplantation, therapeutic effect, and treatment was conducted for articles published from January 12, 2001, to October 1, 2020. Importance Hematopoietic stem cell transplant (HSCT) is an advisable option for refractory or relapsed peripheral T-cell lymphoma (R/R-PTCL), but whether allogeneic HSCT or autologous HSCT is more beneficial is unknown. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.
Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.You'll meet with your care team frequently to watch for side effects and to monitor your body's response to the transplant. Your stem cells will be infused into your bloodstream, where they will travel to your bone marrow and begin creating new blood cells.Īfter your autologous stem cell transplant, you'll remain under close medical care. Talk with your doctor about what you can expect from your treatment. The cancer treatments used during the conditioning process carry a risk of side effects. The treatments you undergo depend on your disease and your particular situation. During the conditioning process, you'll receive high doses of chemotherapy or radiation therapy - or sometimes both treatments - to kill your cancer cells. Undergoing high doses of cancer treatment (conditioning). A machine filters out the stem cells and the rest of your blood is returned to your body.Ī preservative is added to your stem cells and then they're frozen and stored for later use. For stem cell collection, a needle is inserted into a vein in your arm to draw out your blood. You'll receive medications that cause your stem cells to increase in number and to move out of your bone marrow and into your blood, where they can be easily collected.įiltering stem cells from your blood. Taking medications to increase the number of stem cells in your blood.Undergoing an autologous stem cell transplant involves: An autologous stem cell transplant helps to replace the damaged bone marrow.Īn autologous stem cell transplant is most often used to treat: These treatments are likely to damage the bone marrow. Autologous stem cell transplants are typically used in people who need to undergo high doses of chemotherapy and radiation to cure their diseases.
0 kommentar(er)
